HLA B27, ankylosing spondylitis, and some normal rabbit sera.
نویسندگان
چکیده
منابع مشابه
ASSOCIATION OF HLA-B27 WITH ANKYLOSING SPONDYLITIS IN ISFAHAN, IRAN
Using a standard microcytotoxicity (NIH) technique of tissue typing, the HLA-B27 antigen was identified in 30 out of 34 patients (HH.2%) with classical ankylosing spondylitis (AS), compared to 6 out of 70 controls (H.6%) (P < 0.005). We also found this antigen in 8 out of 76 (10.5%) patients with non-AS arthritis.
متن کاملDistribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran
Background: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. Objective: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). Methods: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by ...
متن کاملHLA-B27 associated cross-reactive marker on the cells of New Zealand patients with ankylosing spondylitis.
We have previously shown that antibodies raised in rabbits to certain enteric bacteria will specifically lyse, in a 51Cr release assay, the peripheral blood lymphocytes (PBL) of 80% of HLA-B27 positive patients with ankylosing spondylitis (B27+ AS+) but not the PBL of HLA-B27 positive normal controls (B27+ AS-). Other laboratories have been unable to reproduce these findings. This study was des...
متن کاملStructural identity of human histocompatibility leukocyte antigen-B27 molecules from patients with ankylosing spondylitis and normal individuals.
Although the association between human histocompatibility leukocyte antigen (HLA) B27 and ankylosing spondylitis is the prototype of HLA-disease association, the mechanism underlying these associations has not been determined. We have investigated the possibility that the B27 molecules from patients with ankylosing spondylitis are different from those of normals, and only the "different" molecu...
متن کاملPossible role of enteric organisms in the pathogenesis of ankylosing spondylitis and other seronegative arthropathies.
One-hundred eighty-five clinical isolates of Salmonella sp., Shigella sp., Escherichia coli, and Campylobacter sp. were tested for their ability to absorb the lymphocytotoxic activity of an antiserum (anti-Klebsiella sp. K43) directed against a specific HLA-B27-associated cell surface determinant on the lymphocytes of patients with ankylosing spondylitis (AS). Seven of these isolates (three Sal...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 41 4 شماره
صفحات -
تاریخ انتشار 1982